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Blood cells in mammals do not have a nucleus after they mature for a unique reason among blood-cell hearts. They have nuclei in the early stages of erythropoiesis but shed them during development as they mature; This provides more space for hemoglobin. Nucleus-less red blood cells are known as reticulocytes which subsequently lose all other cellular organelles such as their mitochondria, Golgi apparatus and endoplasmic reticulum.